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Mitragynine (MIT), the primary alkaloid in Kratom, can help with 7-OH withdrawal by partially activating mu-opioid receptors, easing discomfort, pain and cravings. It also influences adrenergic and serotonergic systems, helping reduce anxiety, irritability, and insomnia while improving mood and focus. These chewable tablets are dosed at 50mg per tablet and tastey. Very easy to dose. Be well.

How can the alkaloid Mitragynine help temper 7-OH withdrawal? (And Secondary Alkaloids: Paynantheine= 4.46%, Speciogynine= 3.35%, Speciocillatine = 1.36%) Mitragynine may help with 7-hydroxymitragynine (7-OH) withdrawal because of the way the two alkaloids interact with opioid receptors, but with important differences in potency, efficacy, and receptor activity: **Partial agonist vs. strong agonist:** 7-OH is a much more potent and efficacious μ-opioid receptor (MOR) agonist, producing strong opioid-like effects and dependence liability. Mitragynine, by contrast, is a weaker partial agonist at MOR and also has activity at adrenergic, serotonergic, and dopaminergic receptors. This means mitragynine can provide some opioid tone during withdrawal without driving the same level of receptor saturation and dependence. **Receptor competition and substitution:** Because mitragynine has MOR activity, it may partially substitute for the loss of 7-OH during tapering or withdrawal. This substitution effect can reduce acute withdrawal symptoms such as muscle aches, anxiety, gastrointestinal distress, and dysphoria, though at a lower intensity than 7-OH. **Longer half-life and slower kinetics:** Mitragynine has a longer plasma half-life compared to 7-OH, which means its effects wear off more gradually. This may help smooth out fluctuations in receptor activation, easing the rebound withdrawal intensity that occurs when 7-OH levels drop quickly. **Non-opioid receptor effects that ease withdrawal:** Mitragynine's activity at α-2 adrenergic receptors can reduce sympathetic overdrive (restlessness, sweating, rapid heart rate) often seen in opioid withdrawal. Its interactions with dopamine and serotonin systems may also support mood and motivation during tapering. **Potential harm-reduction strategy:** Using mitragynine in place of 7-OH could be viewed as a step-down approach, where the person transitions from a high-potency, high-risk alkaloid (7-OH) to a lower-potency, more manageable one (mitragynine), before eventually tapering off completely. --- ## Minor Alkaloids (and how they can help) **1. Speciociliatine** - Receptor activity: Acts as a μ-opioid receptor antagonist / very weak partial agonist. - How it helps: By partially blocking MOR activity, it may reduce receptor overstimulation and help normalize opioid receptor tone as someone tapers down. This can ease the "shock" of going from high receptor activation (7-HMG) to zero, making withdrawal symptoms less severe. It may also counterbalance some of mitragynine's partial agonism, smoothing the overall pharmacological profile. **2. Speciogynine** - Receptor activity: Shows little MOR binding, but evidence points to smooth muscle relaxant and GABAergic modulatory effects. - How it helps: Smooth muscle relaxation could reduce intestinal cramping and diarrhea, common opioid withdrawal symptoms. Possible GABAergic effects may provide anxiolysis and muscle calmness, reducing restlessness, tension, and insomnia. By not being strongly opioid-active, it contributes support without perpetuating dependence. **3. Paynantheine** - Receptor activity: Weak MOR partial agonist; also has notable calcium channel–blocking and muscle relaxant effects. - How it helps: Calcium channel blockade can reduce neuropathic pain and hyperexcitability during withdrawal (similar in concept to gabapentinoids). Its muscle relaxant properties may ease restlessness, cramps, and tension. The mild opioid receptor activity could provide a buffer against sudden receptor downregulation, softening withdrawal discomfort.

How can the alkaloid Mitragynine help temper 7-OH withdrawal? (And Secondary Alkaloids: Paynantheine= 4.46%, Speciogynine= 3.35%, Speciocillatine = 1.36%) Mitragynine may help with 7-hydroxymitragynine (7-OH) withdrawal because of the way the two alkaloids interact with opioid receptors, but with important differences in potency, efficacy, and receptor activity: **Partial agonist vs. strong agonist:** 7-OH is a much more potent and efficacious μ-opioid receptor (MOR) agonist, producing strong opioid-like effects and dependence liability. Mitragynine, by contrast, is a weaker partial agonist at MOR and also has activity at adrenergic, serotonergic, and dopaminergic receptors. This means mitragynine can provide some opioid tone during withdrawal without driving the same level of receptor saturation and dependence. **Receptor competition and substitution:** Because mitragynine has MOR activity, it may partially substitute for the loss of 7-OH during tapering or withdrawal. This substitution effect can reduce acute withdrawal symptoms such as muscle aches, anxiety, gastrointestinal distress, and dysphoria, though at a lower intensity than 7-OH. **Longer half-life and slower kinetics:** Mitragynine has a longer plasma half-life compared to 7-OH, which means its effects wear off more gradually. This may help smooth out fluctuations in receptor activation, easing the rebound withdrawal intensity that occurs when 7-OH levels drop quickly. **Non-opioid receptor effects that ease withdrawal:** Mitragynine's activity at α-2 adrenergic receptors can reduce sympathetic overdrive (restlessness, sweating, rapid heart rate) often seen in opioid withdrawal. Its interactions with dopamine and serotonin systems may also support mood and motivation during tapering. **Potential harm-reduction strategy:** Using mitragynine in place of 7-OH could be viewed as a step-down approach, where the person transitions from a high-potency, high-risk alkaloid (7-OH) to a lower-potency, more manageable one (mitragynine), before eventually tapering off completely. --- ## Minor Alkaloids (and how they can help) **1. Speciociliatine** - Receptor activity: Acts as a μ-opioid receptor antagonist / very weak partial agonist. - How it helps: By partially blocking MOR activity, it may reduce receptor overstimulation and help normalize opioid receptor tone as someone tapers down. This can ease the "shock" of going from high receptor activation (7-HMG) to zero, making withdrawal symptoms less severe. It may also counterbalance some of mitragynine's partial agonism, smoothing the overall pharmacological profile. **2. Speciogynine** - Receptor activity: Shows little MOR binding, but evidence points to smooth muscle relaxant and GABAergic modulatory effects. - How it helps: Smooth muscle relaxation could reduce intestinal cramping and diarrhea, common opioid withdrawal symptoms. Possible GABAergic effects may provide anxiolysis and muscle calmness, reducing restlessness, tension, and insomnia. By not being strongly opioid-active, it contributes support without perpetuating dependence. **3. Paynantheine** - Receptor activity: Weak MOR partial agonist; also has notable calcium channel–blocking and muscle relaxant effects. - How it helps: Calcium channel blockade can reduce neuropathic pain and hyperexcitability during withdrawal (similar in concept to gabapentinoids). Its muscle relaxant properties may ease restlessness, cramps, and tension. The mild opioid receptor activity could provide a buffer against sudden receptor downregulation, softening withdrawal discomfort.

How can the alkaloid Mitragynine help temper 7-OH withdrawal? (And Secondary Alkaloids: Paynantheine= 4.46%, Speciogynine= 3.35%, Speciocillatine = 1.36%) Mitragynine may help with 7-hydroxymitragynine (7-OH) withdrawal because of the way the two alkaloids interact with opioid receptors, but with important differences in potency, efficacy, and receptor activity: **Partial agonist vs. strong agonist:** 7-OH is a much more potent and efficacious μ-opioid receptor (MOR) agonist, producing strong opioid-like effects and dependence liability. Mitragynine, by contrast, is a weaker partial agonist at MOR and also has activity at adrenergic, serotonergic, and dopaminergic receptors. This means mitragynine can provide some opioid tone during withdrawal without driving the same level of receptor saturation and dependence. **Receptor competition and substitution:** Because mitragynine has MOR activity, it may partially substitute for the loss of 7-OH during tapering or withdrawal. This substitution effect can reduce acute withdrawal symptoms such as muscle aches, anxiety, gastrointestinal distress, and dysphoria, though at a lower intensity than 7-OH. **Longer half-life and slower kinetics:** Mitragynine has a longer plasma half-life compared to 7-OH, which means its effects wear off more gradually. This may help smooth out fluctuations in receptor activation, easing the rebound withdrawal intensity that occurs when 7-OH levels drop quickly. **Non-opioid receptor effects that ease withdrawal:** Mitragynine's activity at α-2 adrenergic receptors can reduce sympathetic overdrive (restlessness, sweating, rapid heart rate) often seen in opioid withdrawal. Its interactions with dopamine and serotonin systems may also support mood and motivation during tapering. **Potential harm-reduction strategy:** Using mitragynine in place of 7-OH could be viewed as a step-down approach, where the person transitions from a high-potency, high-risk alkaloid (7-OH) to a lower-potency, more manageable one (mitragynine), before eventually tapering off completely. --- ## Minor Alkaloids (and how they can help) **1. Speciociliatine** - Receptor activity: Acts as a μ-opioid receptor antagonist / very weak partial agonist. - How it helps: By partially blocking MOR activity, it may reduce receptor overstimulation and help normalize opioid receptor tone as someone tapers down. This can ease the "shock" of going from high receptor activation (7-HMG) to zero, making withdrawal symptoms less severe. It may also counterbalance some of mitragynine's partial agonism, smoothing the overall pharmacological profile. **2. Speciogynine** - Receptor activity: Shows little MOR binding, but evidence points to smooth muscle relaxant and GABAergic modulatory effects. - How it helps: Smooth muscle relaxation could reduce intestinal cramping and diarrhea, common opioid withdrawal symptoms. Possible GABAergic effects may provide anxiolysis and muscle calmness, reducing restlessness, tension, and insomnia. By not being strongly opioid-active, it contributes support without perpetuating dependence. **3. Paynantheine** - Receptor activity: Weak MOR partial agonist; also has notable calcium channel–blocking and muscle relaxant effects. - How it helps: Calcium channel blockade can reduce neuropathic pain and hyperexcitability during withdrawal (similar in concept to gabapentinoids). Its muscle relaxant properties may ease restlessness, cramps, and tension. The mild opioid receptor activity could provide a buffer against sudden receptor downregulation, softening withdrawal discomfort.

**Typical Dosage:** 30mg maximum before bed for sleep or rest. Milligram (mg) scale needed for accurate dosing. ***Not to be taken every day*** **Main Effects:** - Light Pain relief - Anxiolytic properties - Sleep induction - May help curb addiction and cravings - Possible dopamine receptor antagonism (can blunt reward-seeking behavior) *Not FDA approved to cure or treat any disease.*

**Typical Dosage:** 30mg maximum before bed for sleep or rest. Milligram (mg) scale needed for accurate dosing. ***Not to be taken every day*** **Main Effects:** - Light Pain relief - Anxiolytic properties - Sleep induction - May help curb addiction and cravings - Possible dopamine receptor antagonism (can blunt reward-seeking behavior) *Not FDA approved to cure or treat any disease.*

This product is a DIY nasal spray DSIP kit. It comes with the following: 5mg DSIP peptide, 5ml reconstitution solution, syringe, nasal sprayer, and alcohol wipes. The kit comes with an informational that provides a link to video instructions of how to make your own DSIP nasal spray. Can DSIP help with opioid tapering and withdrawal symptoms? Delta Sleep-Inducing Peptide (DSIP) can be highly beneficial during opioid withdrawal because it helps restore the brain’s natural sleep cycles, calm the nervous system, and reduce the stress and anxiety that often accompany detox. By promoting deep, restorative sleep, DSIP allows the body to recover from the physical and emotional strain of withdrawal while supporting balance in neurotransmitters like GABA and serotonin. Its neuroprotective and anti-stress properties can also lessen irritability, restlessness, and insomnia—making DSIP a gentle, natural aid for stabilizing mood, improving sleep quality, and easing the overall withdrawal process. Gamechanger....

NAD+ offers a powerful, restorative boost for individuals navigating an opioid taper, helping the body maintain energy, clarity, and balance during a challenging transition. Known for its role in cellular repair and mitochondrial function, NAD+ supports natural vitality, combats fatigue, and promotes sharper cognitive function—areas that are often strained during withdrawal. Many users report feeling more steady, clear-headed, and energized as NAD+ helps replenish what long-term stress on the body can deplete. During opioid tapering, the nervous system is working hard to recalibrate. NAD+ may support this process by promoting a more stable mood, encouraging better sleep patterns, and helping reduce the sense of physical and mental “drag” that can accompany tapering and withdrawal. While not a treatment for dependency, NAD+ can be a valuable wellness ally, helping the body feel more balanced and resilient as individuals work toward recovery and improved well-being. If you’re seeking a cleaner, more supported transition, NAD+ is a smart addition to your tapering toolkit.

Premium San Pedro Cactus Cutting — Sacred, Resilient, and Ready to Grow ***Price is for 12" cutting.*** Bring home a living piece of ancient botanical heritage with our healthy, sustainably sourced San Pedro cactus cutting. Celebrated for centuries in Andean cultures, this fast-growing, columnar cactus is prized today by collectors for its striking beauty, vibrant green skin, and rich historical significance. While the species is well known in anthropological literature for containing mescaline, our product is sold strictly for ornamental, horticultural, and educational purposes only. This cutting roots easily with proper care, thrives both indoors and outdoors, and develops into a majestic, sculptural plant that makes a bold centerpiece in any collection. Whether you’re an enthusiast of ethnobotanical history, a cactus collector, or simply someone who appreciates unique and meaningful plants, this is a chance to cultivate a living symbol of resilience, tradition, and natural elegance—right from your home. ***Price is for 12" cutting.*** Modern research is shining new light on how psychedelic-assisted therapy—conducted legally, ethically, and under trained clinical supervision—may transform the future of mental health care. Studies from leading institutions suggest that psychedelic compounds, when administered in controlled therapeutic settings, may help individuals break through treatment-resistant depression, reduce anxiety, ease the emotional burden of PTSD, and support healthier cognitive and emotional patterns. ***Price is for 12" cutting.*** Be Well. Be Good To Yourself.

This product is a DIY nasal spray Semax and Selank kit. It comes with the following: 10mg Selank and 10mg of Semax peptides, 10ml reconstitution solution, two syringes, two nasal sprayers, and alcohol wipes. The kit comes with an informational that provides a link to video instructions of how to make your own Semax and Selank stacked nasal spray. Selank + Semax is a synergistic peptide stack designed for those who want balanced calm, sharp focus, and elevated cognitive performance—all in one formula. Selank delivers smooth anxiolytic support by modulating GABA and stabilizing stress-related neurotransmitters, helping you stay grounded, centered, and emotionally steady. Semax complements this by enhancing dopamine pathways, boosting BDNF, and promoting heightened focus, memory, and mental clarity. Together, they create a clean, non-sedating blend that helps you think clearly under pressure while maintaining a calm, confident mindset. This dual-action stack is ideal for high-stress workdays, demanding study sessions, or any situation where you need clear thinking without anxiety or overwhelm. Users often report improved productivity, smoother mental energy, better mood stability, and enhanced cognitive endurance. Whether you're optimizing daily performance, supporting long-term brain health, or looking for an edge in focus and stress resilience, the Selank + Semax combination delivers a powerful, fast-acting nootropic experience that keeps you sharp, steady, and consistently at your best.

This product is a DIY nasal spray Selank kit. It comes with the following: 10mg Selank peptide, 5ml reconstitution solution, syringe, nasal sprayer, and alcohol wipes. The kit comes with an informational that provides a link to video instructions of how to make your own Selank nasal spray. Selank is a powerful anxiolytic peptide formulated to promote calm, clarity, and emotional balance without sedation. Originally developed for clinical use in managing anxiety and stress-related conditions, Selank works by modulating GABA and influencing key neurotransmitters associated with relaxation and mental stability. Users often describe a smooth, grounded sense of calm paired with improved focus—making it an excellent choice for high-stress work, social situations, or everyday mental wellness. Its nasal spray format offers fast, convenient absorption for reliable support exactly when you need it. Beyond its calming effects, Selank is also known for supporting cognitive function, memory, and immune modulation. Research suggests it may help enhance mental performance under pressure, stabilize mood, and assist with more consistent emotional regulation throughout the day. Whether you're seeking a gentle daily anxiolytic or a natural aid for productivity and stress resilience, Selank provides a clean, non-habit-forming option to help you feel centered, clear-headed, and in control.

This product is a DIY nasal spray Semax kit. It comes with the following: 10mg Semax peptide, 5ml reconstitution solution, syringe, nasal sprayer, and alcohol wipes. The kit comes with an informational that provides a link to video instructions of how to make your own Semax nasal spray. Semax is a potent nootropic peptide designed to support peak cognitive performance, mental clarity, and stress resilience. Originally developed in Russia for neurological and post-stroke recovery, Semax is known for its ability to enhance focus, sharpen memory formation, and promote healthier neurotransmitter balance—especially within dopaminergic and neurotrophic pathways. Many users report clearer thinking, smoother mental energy, and improved productivity without the jitteriness associated with stimulants. Its fast-acting nasal delivery makes it ideal for those who want immediate support during demanding work, study, or high-pressure environments. Beyond cognitive enhancement, Semax is valued for its potential neuroprotective and mood-balancing effects. It may help support the brain’s natural response to stress, improve resilience, and promote long-term neurological wellness by increasing BDNF (brain-derived neurotrophic factor) and modulating beneficial peptide systems. Whether you’re looking to optimize performance, boost mental stamina, or support overall brain health, Semax offers a clean, modern approach to elevated cognition and daily focus.

Price is for 1 gram of: 5,6-Dichloro Desmethylchlorphine Discover high-purity SR-17018 designed for advanced scientific, analytical, and forensic research applications. Each batch is of consistent quality, stability, and reliability for your experiments. ✅ High Purity & Verified Quality ✅ Packaged & Labeled for Research Applications ✅ Suitable for Analytical, Calibration, and Assay Work ⚠️ Important Notice: This product is strictly intended for laboratory research and analytical purposes only. It is not for human consumption, veterinary use, or therapeutic application. Always handle in accordance with proper laboratory safety protocols. Weight: 1 gram

With the Anti-Mu Taper and Withdrawal Kit, you can ease your withdrawal journey with the powerful synergy of L-Theanine, Bacopa Monnieri, and Magnesium Glycinate—a natural trio designed to calm the mind, support cognitive clarity, and relax the body. **L-Theanine** promotes a deep sense of calm without sedation, helping to reduce anxiety and restlessness. **Bacopa** supports mood stability and mental focus during detox, while also protecting the nervous system from stress. **Magnesium Glycinate** (for nighttime) is a highly absorbable form of magnesium that soothes muscle tension, improves sleep quality, and replenishes essential minerals often depleted during withdrawal. Together, they create a gentle, non-addictive formula that supports both body and mind through the toughest moments of recovery. **Get your kit today! Be Well.**

With the Anti-Mu Taper and Withdrawal Kit, you can ease your withdrawal journey with the powerful synergy of L-Theanine, Bacopa Monnieri, and Magnesium Glycinate—a natural trio designed to calm the mind, support cognitive clarity, and relax the body. **L-Theanine** promotes a deep sense of calm without sedation, helping to reduce anxiety and restlessness. **Bacopa** supports mood stability and mental focus during detox, while also protecting the nervous system from stress. **Magnesium Glycinate** (for nighttime) is a highly absorbable form of magnesium that soothes muscle tension, improves sleep quality, and replenishes essential minerals often depleted during withdrawal. Together, they create a gentle, non-addictive formula that supports both body and mind through the toughest moments of recovery. **Get your kit today! Be Well.**

Find Relief Naturally: The Power of Alkaloids for an alternative to 7-Hydroxymitragynine (7-OH). Struggling with 7-OH? Do you desire pain relief that doesn't have the attributes of dependency The path to relief may lie in this balanced synergy of four key kratom-derived alkaloids: mitragynine (23.4%), paynantheine (22.0%), speciogynine (7.70%), and speciociliatine (6.00%). Unlike 7-hydroxymitragynine — a potent mu-opioid agonist — these alkaloids offer a gentler, stabilizing effect on your receptors. Mitragynine helps reduce cravings and supports mood regulation, while paynantheine and speciogynine act as smooth muscle relaxants, aiding physical comfort during withdrawal. Speciociliatine, with its mild sedative properties, may ease anxiety and support restful sleep. Together, these natural compounds create a supportive, non-intoxicating matrix that may ease both physical and psychological symptoms — without the sharp rebound effect of more potent opioids. **Reclaim your balance. Reduce the discomfort. Choose plant-based support for your recovery journey.**

Find Relief Naturally: The Power of Alkaloids for 7-Hydroxymitragynine Tapering Struggling to taper 7-hydroxymitragynine? The path to relief may lie in this balanced synergy of four key kratom-derived alkaloids: mitragynine (23.4%), paynantheine (22.0%), speciogynine (7.70%), and speciociliatine (6.00%). Unlike 7-hydroxymitragynine — a potent mu-opioid agonist — these alkaloids offer a gentler, stabilizing effect on your receptors. Mitragynine helps reduce cravings and supports mood regulation, while paynantheine and speciogynine act as smooth muscle relaxants, aiding physical comfort during withdrawal. Speciociliatine, with its mild sedative properties, may ease anxiety and support restful sleep. Together, these natural compounds create a supportive, non-intoxicating matrix that may ease both physical and psychological symptoms — without the sharp rebound effect of more potent opioids. **Reclaim your balance. Reduce the discomfort. Choose plant-based support for your recovery journey.**

Find Relief Naturally: The Power of Alkaloids for 7-Hydroxymitragynine Tapering Struggling to taper 7-hydroxymitragynine? The path to relief may lie in this balanced synergy of four key kratom-derived alkaloids: mitragynine (23.4%), paynantheine (22.0%), speciogynine (7.70%), and speciociliatine (6.00%). Unlike 7-hydroxymitragynine — a potent mu-opioid agonist — these alkaloids offer a gentler, stabilizing effect on your receptors. Mitragynine helps reduce cravings and supports mood regulation, while paynantheine and speciogynine act as smooth muscle relaxants, aiding physical comfort during withdrawal. Speciociliatine, with its mild sedative properties, may ease anxiety and support restful sleep. Together, these natural compounds create a supportive, non-intoxicating matrix that may ease both physical and psychological symptoms — without the sharp rebound effect of more potent opioids. **Reclaim your balance. Reduce the discomfort. Choose plant-based support for your recovery journey.**